Heartburn can be uncomfortable, but heart attacks can be fatal, which is why the FDA has investigated a suspected link between cardiac trouble and the acid-reflux remedies Prilosec and Nexium. In December 2007, the agency concluded that there was no “likely” connection. Translation: The scientific jury is still out. In the meantime, there are other reasons to be concerned. Because Prilosec and Nexium are proton-pump inhibitors, they are both incredibly effective at stopping acid production in the stomach—perhaps too effective.

A lack of acid may raise your risk of pneumonia, because the same stuff that makes your chest feel as if it’s burning also kills incoming bacteria and viruses. You may also have an elevated risk of bone loss—in the less acidic environment, certain forms of calcium may not be absorbed effectively during digestion. “The risk of a fracture has been estimated to be over 40 percent higher in patients who use these drugs long-term, and the risk clearly increases with duration of therapy,” says Dr. Rodgers.

Your New Strategy
When you feel the fire, first try to extinguish it with Zantac 150 or Pepcid AC. Both of these OTC products work by blocking histamine from stimulating the stomach cells that produce acid. Just know that neither drug is a long-term fix.

“To really cure the problem, lose weight,” says Michael Roizen, M.D., chief wellness officer at the Cleveland Clinic and coauthor of YOU: The Owner’s Manual. That’s because when you’re overweight, excess belly fat puts pressure on and changes the angle of your esophagus, pulling open the valve that’s supposed to prevent stomach-acid leaks. This in turn makes it easier for that burning sensation to travel up into your chest.